Endocrine Abstracts

Abstract: Obesity results from an imbalance between caloric intake and energy expenditure. Specialized neurons of the hypothalamus coordinately control the integration between feeding and thermogenesis and a defective regulation of these parameters contribute to the progressive accumulation of body fat. Recent studies have revealed that at least part of hypothalamic dysfunction contributing to the development of obesity results from the activation of a local inflammatory respo...

Leptin is an adipocyte-derived hormone that acts directly in the brain reducing food intake, increasing glucose uptake and modulating the metabolism in adipose tissue. Nevertheless, the central mechanisms related to improve glucose uptake, induced by leptin intracerebroventricular (icv), and the proteins activated in the skeletal muscle are incompletely understood. The aim of this study was to investigate the mechanism by which ICV leptin increase glucose uptake and improve gl...